Edit: Thanks for your kind comments on disabling contributions. I'm aware of the possibility, this is just a meme.
Contributions in open source projects are great, needed and make the world a better place after all. Therefore they should be declined politely, optionally by giving a reason.
I hereby inform you that I will no longer accept contributions to this post /s.
No you can't. The only way to turn off PRs on a public repo is to migrate away from GitHub.