Yes, Guix is initially a clone of Nix and has still remains of shared code (the build daemon).
Differences:
- Guix packages are defined in a Scheme dialect called Guile, a nice minimal functional language
- Guix was created as a GNU project and stresses the importance of free software with strong copyleft
- strong focus on long-term reproducibility and capability of tracking the sources
- everything is built from source
- very good and well organized documentation
Guix is not a small distro any more and has a lot of support. Yes it has more packages than Arch - but this is hardly an argument against it. It is built on different principles compared to the Arch user repository - keeping control of the own computer was always a core goal of GNU, and this logically includes security from malware.