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First-In-Human Trial Of CRISPR Gene-Editing Therapy Safely Lowered Cholesterol, Triglycerides
(finance.yahoo.com)
Nerds will do anything not to go for a jog
this post was submitted on 14 Jan 2026
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to be fair, jogging is kinda the worst.
Nerd
Bring it on!!!
Autoimmune disease? GONE!
Acne? GONE!
Don't like your eye color? CHANGE IT!
For rich by rich, only rich get.
Thats not really true.
The US is an exception but generally, the cost of therapies becomes commercially viable with the passage of time.
For example, our 2 year old daughter just had her DNA profiled because she has a few manageable, yet ongoing developmental deficiencies. Her DNA markers will guide her treatment.
When I was a child this type of treatment was sci-fi, and when it was invented you could have said "by rich for rich" or whatever.
Cost and price are two different things. Insulin is cheap to make but people die from not being able to afford the sticker price.
.... In the US, yes
Not outside the US
The US is an exception
Despite my other comments, I suspect you are right.
Now, sing with me: “Only in America…”
Shit's going to get pretty weird imo. Hopefully it isn't used for eugenics purposes (it probably will be, let's be honest). I don't think that people should be able to change so many things that they become unrecognizable, but I can understand changing a few things per person, voluntarily, obviously.
I believe in bodily autonomy. People should be able to do whatever they want to their own body.
Allowed, sure, just don't think it's a good idea to completely change who you are. I want humans to be recognizable as such. I'm more worried about what parents will be doing to their children, that's where the eugenics shit becomes a problem. Getting rid of "undesirable" traits and whatnot.
There are a lot more problems in trying to create the infrastructure to enforce sanctioned uses of any readily accessible technology than there is in the use of said tool. The people who want to do the most harm inevitability wind up in the oversight position, while society tends to create enforcement mechanisms at a social, interpersonal level organically already.
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(4 replies)
And enjoy the 5 cancers you just caused yourself by editing other genes that happen to contain the targeted sequence !
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Is this the first human trial, or just the first officially sanctioned one?
IIRC there was that one guy who experimented on himself and cured his lactose intolerance.
... found it: https://www.youtube.com/watch?v=J3FcbFqSoQY
Nearly 8 years ago.
I feel obligated to mention that he doesn't modify his own genes, he infects himself with a modified bacteria that produces lactase.
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First-in-human just means it's the first time that specific therapy is being tested on humans instead of animals (e.g. mice, dogs, monkeys), and the primary objective of the trial is to test that it's safe for use in humans. It doesn't refer to the concept of gene editing or lowering cholesterol.
was safe and reduced LDL cholesterol by nearly 50% and reduced triglycerides by about 55%
From the referenced article
What is the point of your comment?
Thought emporium?
Yep thought emporium.
~~But I think the Chinese scientist that experimented on babies did it few years before that even.~~ looks like same year, 2018, and thought emporium published first by 8 months
That paper is a wild read
We lowered your cholesterol. But you now have horns and crave the taste of human flesh.
I don't understand why you used "but", where it should clearly be "as well as"...
With what "side" effects?
Rich people living longer
That is indeed a very heavy side effect and could potentially be a threat to human life on this planet.
Anything not to eat less butter, huh?
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