Last summer through fall I restarted drinking after nearly a decade of very light occassional drinking, about 12 or more ipa's a day, two hearted ipa and a local one.
Roomate was cool but drank a liter of scotch a day, happy drunk though, both of us. Worst he did was exitedly tell or play things for you he had previously, especially of his glory days.
There was a study in British Columbia around 2017 or so where they gave brain damaged rats some super potent form of THC in massive quantities and those rats reprogrammed and rewired their brain damaged brains while the control group did not.