this post was submitted on 07 Jul 2026
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Does rotating them actually work? I thought they all just blocked your histamine receptors, so your body couldn't care less just which substance did that for expressing more histamine receptors / making more histamine, thereby developing tolerance.
Edit: Yeah, so I hate to place a nocebo here, but taking a break, not rotating them, seems to be the only effective remedy to anti-histamine tolerance. That is, if taking a break is tolerable, of course. I don't know if that has to be said but please take medical advice from your health care professional of choice and not from a lemmy comment.
https://www.jacionline.org/article/0021-8707%2851%2990033-0/fulltext
I mean this is anecdote so take it as you will, but the rotating advice is straight from my own doc after we bitched about benadryl not working anymore.
Granted, this was a solid 20 or so years ago, so new findings and best practice are expected.
But, benadryl remains a dud for me, while I haven't developed a tolerance to any of the others.
Glad it helps you get by! I hadn't heard of the rotating antihistamines trick and was curious about the mechanism, so I asked Dr. DuckDuckGo. Could've always been some other tolerance mechanism, like faster breakdown of the drug, which rotating might help with. The paper does mention benadryl and a handful of other substances, but it's also ancient by research standards, so I don't know if that applies to all antihistamines or if some circumvent tolerance induction somehow.