The only reason I keep Facebook is for unhinged stuff like this
this post was submitted on 19 Jul 2026
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My pharma professors liked to say that if Aspirin was discovered today, it would never pass the bar for human trials, because after all these years the mechanism of action isn't properly understood.
That's the best argument for alternative medicines that I've heard, and it's also something to consider when we think about how insanely high the bar is for compounds that are approved as medicines.
That wasn't a blocker with antidepressants, for better or worse.
I wonder if thats because we know very little about how the brain actually works in regards to how the brain create thoughts. It's so very much a mystery in many ways where thoughts are created
Most medications are poorly understood (at best!) lol, it's trial and error all the way down.
With some exceptions like the RNA messenger covid vaccine...
Oh God LD50 is the craziest thing ever.
Here's how it works:
Let's just assume dose-response is linear. So, go find what concentration of chemical X (medicine, food additive, cosmetic, whatever) kills 50% of the bacteria/rodent/etc population. Draw a line from there down to 0% dead at 0 concentration.
Now decide what % of deaths is acceptable, given the benefit of chemical X. Use the line we just drew and that tells you what the regulations should set for max concentration under as-directed usage.
This ignores facts like
It's a combinatorial explosion we can never meaningfully test against. We do what we can, with the tools that we have.
Almost every signal response, and certainly in chemistry, is an S curve. A small span of that curve may be approximately linear, but you absolutely can not approximate the slope of that linear span by just the mid point.