I suspect it would be since it would contain the same information, however, unless I was misinformed last time I looked into that (for scifi worldbuilding, so not terribly serious a search admittedly), the computational requirements to run a full physics simulation of a brain at that detailed of a resolution are probably just too high to ever be practical.

That being said, I really doubt you need to simulate one to the subatomic level, since the basic unit of a brain appears to be the nerve cells, and stuff more fundamental than that just provides the physical basis for those cells to work. Simulate the behavior of neurons accurately enough, and arrange them in the right way, and I'd personally be willing to bet theyd be sentient even if the simulation doesnt model every subatomic interaction within each neuron and just simulates something with the same output for a given input as an average neuron of the relevant type. The difficulty of that shouldn't be understated, I would not be surprised if theres important but subtle behaviors in biological neurons that we've not discovered yet, and even if there arent, we'd want to be sure of it, and more importantly, "arranging them in the right way" is not (I would bet at least) a trivial problem, your brain is after all more detailed than just a lump of identical neurons that form connections at random, it has distinct structures that do distinct things, and that makes me think that the stuff we care about, like consciousness, is probably something resulting from arranging neurons in a specific kind of way, rather than just "thing that happens if you connect a large enough of them together", else thered be no pressure for those structures to evolve.

On the other hand, I dont see any particular reason to assume that our brains are the most efficient or only way to do sentience. They exist because of a process of evolution acting on random mutation, not directed design, and while that can make some pretty efficient things, it wont find every solution, because every intermediate step has to be evolutionarily favorable as well and some things wont be that helpful half-made. As such, brains surely must represent at least an upper ceiling on the minimum resources required for sentience. A sentient thing using the amount of energy and matter that a human brain uses is definitely possible, because we observe them, but we have no indication that one smaller or more energy efficient cant exist. Maybe there are some processes that neurons do that have affects on their output, but which arent big enough to have an impact on sentience and can be abstracted away, for example. Im not sure exactly how that translates into the amount of compute you'd need, because brains are of course not digital computers, and simulating one with a digital computer is an extra step over just making a structure that directly does the stuff brains do.

Im not an neuroscientist or an AI or computer science expert and I imagine the intersection of those fields is where youd find the kind of person that could really give a useful answer. My gut feeling is that, given that humans dont need such massive amounts of energy to run or all the world's information to train our minds, that our current way of doing AI is fundamentally extremely inefficient, and if some way can be found to create sentience with the technology we have, theres probably also a lot of room for making it more efficient too, to the point that I would be unsurprised if we have the compute needed already and just dont yet know how to actually use it to create that result. I kind of hope that its not figured out for awhile though- not because I think that a sentient AI would take over the world or something but just that, well, an actual sentient AI would hypothetically be a person, by many standards, and I see no way that, being created by corporations seeking a return on investment and with no legal rights whatsoever, it wouldnt just be a very high tech slave with all the ethical issues that poses and more. So, I hope that it takes long enough to figure that all out for the system that develops that technology to be replaced with something different, and hopefully more thoughtful for the ethics of it all. Thats probably wishful thinking on my part, but its something thats worried me about the whole AI boom. I dont think that what's currently being sold is really as smart or capable as the marketing makes it out to be, but also that if it was, it wouldnt be ethical to use it as just a tool, and either way that doesnt paint the AI industry in a good light. Not that I really need to convince lemmy that theres something rotten there given its general sentiment towards AI.