this post was submitted on 20 Dec 2025
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[–] KingOfSuede@lemmy.world 166 points 1 month ago (1 children)

Salient points for those who don’t want to read the article, or can’t:

  • The team administered a single shot of E. americana intravenously to mice with colorectal cancer, and it completely eliminated tumors in every treated animal.

  • Caused only short-lived inflammatory effects that resolved within 72 hours

  • Over two months of observation, treated mice showed no signs of organ damage or chronic toxicity.

  • The bacterium are also sensitive to antibiotics, providing intervention options if problems were to arise following treatment.

  • When the mice were later re-exposed to cancer cells, none developed new tumors, suggesting the treatment had triggered long-lasting immune memory.

This holds some real promise, I’m very excited to see what this brings! Kudos to the researchers!

[–] UltraBlack@lemmy.world 18 points 1 month ago (2 children)

Mfw bacteria become resistant: 😱😱😱

[–] BuboScandiacus@mander.xyz 14 points 1 month ago (2 children)

Still probably better than cancer, no ?

[–] musubibreakfast@lemmy.world 6 points 1 month ago

Yes, now you have to shove a live frog up your ass every day or die of colon cancer.

[–] UltraBlack@lemmy.world 3 points 1 month ago (1 children)

Multiresistant bacteria are a death sentence in many cases...

[–] IAmNorRealTakeYourMeds@lemmy.world 2 points 1 month ago (1 children)
[–] acockworkorange@mander.xyz 1 points 1 month ago

In many cases it isn't.

[–] RVGamer06@sh.itjust.works 2 points 1 month ago* (last edited 1 month ago)

Le epic bacteriophage:

[–] zakobjoa@lemmy.world 67 points 1 month ago (4 children)

Just a minute at 2000°C also eliminated all cancer cells in mice.

[–] First_Thunder@lemmy.zip 41 points 1 month ago (2 children)

Impact on the remaining cells still requires further studying

[–] Test_Tickles@lemmy.world 21 points 1 month ago

It turns out that the witch who turned the prince into a frog was actually curing his cancer not cursing him.

[–] BootLoop@sh.itjust.works 2 points 1 month ago

That is outside of the scope of this study however.

[–] MonkderVierte@lemmy.zip 23 points 1 month ago (2 children)
[–] bdonvr@thelemmy.club 9 points 1 month ago (1 children)

Did we read the same paper? Not a single case of regression after treatment.

[–] XM34@feddit.org 5 points 1 month ago (2 children)

They were talking about the downsides of treatment via 2000 °C.

[–] bdonvr@thelemmy.club 5 points 1 month ago (1 children)

Yeah so was I. But they're wrong, like I said no specimen had cancer return after the 2000⁰C treatment.

[–] jmill@lemmy.zip 3 points 1 month ago

True, but by a different mechanism. Immune memory was not involved in their continued resistance.

[–] MonkderVierte@lemmy.zip 1 points 1 month ago

oh, the immune system will remember, all your cells will remember

[–] TypFaffke@feddit.org 21 points 1 month ago* (last edited 1 month ago)

Ah yes, Thermotherapy

[–] Engywuck@lemmy.zip 2 points 1 month ago

I bet I can do the same in under 10 s.

[–] RacerX@lemmy.zip 25 points 1 month ago

Awesome!

... we'll never hear about this again.

[–] Konstant@lemmy.world 23 points 1 month ago

Getting news from memes is next level.

[–] lurch@sh.itjust.works 21 points 1 month ago (2 children)

afraid to ask: did it also eliminate the mice?

[–] ElderReflections@fedia.io 43 points 1 month ago (1 children)

What's more, the response wasn’t just rapid but appeared to provide ongoing protection. When the mice were later re-exposed to cancer cells, none developed new tumors

Apparently it made them stronger

[–] ShinkanTrain@lemmy.ml 19 points 1 month ago

Please stop praying for my mice, they've become too strong. One of them chewed through the fridge

[–] Manjushri@piefed.social 7 points 1 month ago (1 children)

Quite the contrary...

first, it has a natural affinity for the low-oxygen environment inside solid tumors, so within just 24 hours it had increased its numbers by around 3,000-fold, but it also didn't drift over to impact any other healthy organs or tissue. Then it's able to directly kill the growth thanks to toxins it secretes inside the tumor.

At the same time, the bacterial invasion triggered a natural immune response, and the tumors soon became flooded with immune cells – particularly neutrophils, and T and B cells – alongside increases in inflammatory signaling molecules. The combined effect was widespread tumor cell death driven both by direct bacterial action from the foreign gut bug and by the host’s own immune system.

...

Importantly, this mechanism appears to also be highly tumor-specific, with E. americana sticking only to the tumor environment. The researchers believe this selectivity arises from a combination of factors unique to tumors – insufficient oxygen (hypoxia), leaky blood vessels, altered metabolism and locally suppressed immune defenses that allow the bacterial colony to thrive where they are also most destructive.

[–] untorquer@lemmy.world 2 points 1 month ago

Shit thats a lot of promising routes of action and modulation.

[–] Deestan@lemmy.world 20 points 1 month ago (1 children)
[–] ShinkanTrain@lemmy.ml 10 points 1 month ago (1 children)

How do you administer handgun for colon cancer? 😳

[–] Deestan@lemmy.world 7 points 1 month ago (1 children)

You shouldn't. The side effects turn out to usually be more harmful than the cancer.

[–] BuboScandiacus@mander.xyz 5 points 1 month ago

Skill issue

[–] SaharaMaleikuhm@feddit.org 13 points 1 month ago (2 children)

Do I eat frog poop or should I suckle on their anus for best results?

[–] pewpew@feddit.it 1 points 1 month ago* (last edited 1 month ago)

Neither. Vore time

[–] shalafi@lemmy.world 9 points 1 month ago (1 children)

This is my argument for government science budgets.

Headline: Scientists Spend Millions Studying Andean Frog Fucking Habits!

"What a waste!"

What if I told you those scientists were making more frogs to study how they can freeze solid and thaw out? Or how limb regeneration works?

Practically all meds come from science like that.

why are you studying Easter island soil? discovery of Rapamicin and the cell cenesense pathways in human cells.

[–] Luvs2Spuj@lemmy.world 9 points 1 month ago (1 children)

If this takes off it could be a great thing for conservation. Frogs are in a lot of trouble!

Sadly I'm not so sure, but I like to be optimistic

[–] untorquer@lemmy.world 3 points 1 month ago

If this ~~takes off~~

Leaps off

[–] West_of_West@piefed.social 7 points 1 month ago

Gale: Stop licking the damn thing!

[–] NigelFrobisher@aussie.zone 4 points 1 month ago

They needn’t worry unless the mouse experimental animal Union is more powerful than theirs.

[–] thenewred@lemmy.world 1 points 1 month ago

:bufo-offers-gut-bacterium:

[–] robocall@lemmy.world 1 points 1 month ago

I am down to get some frog gut shots

[–] Asidonhopo@lemmy.world 1 points 1 month ago

Could be we just aren't eating enough uncooked whole, live frogs in our modern diet. Someone has to volunteer to gulp down a few to see if their probiotics cure their cancer, throw some newts in for good measure. If we don't get proof that works at a citizen science level, pharma companies will at best brew the bacteria in a lab and sell it back to us at exorbitant prices. Who will be the next Jonas Salk?